ATAVON-PRO TABLETS
Atovaquone is a ubiquinone analogue used to treat infections caused by protozoa and is often combined with other drugs to treat specific infections. It is the drug of choice for Babesia gibsoni infection in Dogs and Cytauxzoon felis infection in cats.
Proguanil, also known as chloroguanide, is a medication used to treat infections caused by protozoa and often used together with atovaquone.
Composition: Each uncoated chewable tablet contains Atovaquone USP 250mg and Proguanil Hydrochloride IP 100mg.
Storage: Store in a cool, dry place at room temperature. Keep the medicine out of reach of children.
Dosage:
Atovaquone 12.5 mg/kg body weight and Proguanil 5 mg/kg body weight in combination with Azithromycin 10mg/kg body weight and Artesunate 12.5mg/kg body weight once in a day for 10 days.
Pharmacodynamics: Atovaquone is a competitive inhibitor of ubiquinol, specifically inhibiting the mitochondrial electron transport chain at the bc1 complex. Inhibition of bc1 results in a loss of mitochondrial function. Atovaquone potentially causes inhibition of both purine and pyrimidine biosynthesis. Proguanil is a biguanide derivative that is converted to an active metabolite called cycloguanil. It exerts its anti-parasitic action by inhibiting parasitic dihydrofolate reductase enzyme. It has casual prophylactic and suppressive activity against parasite and cures the acute infection.
Indications:
It is indicated with combination drug for the treatment of Relapsing Babesiosis in dogs, The combination drugs include ATAVON-PRO, MACROZEE & ARTEBABE for the treatment of Relapsing Babesiosis in Dogs and ATAVON-PRO, MACROZEE, ARTEBABE and IMIDOPET for the treatment of Tick Fever caused by mixed infection due to B. canis, B. gibsoni, E. canis, A. platys and H. canis.
Directions for Use: Use either whole tablet or split it as required for administration. Always Give fatty diet while giving ATAVON-PRO to increase the Drug absorption. In case of Azithromycin, it should be given in empty stomach preferably in morning time.
Side effects: Atovaquone has a favourable safety profile and appears to have no report of adverse reactions. Proguanil has a high safety margin and reports of severe adverse effects are rare. Temporary hair loss and mouth ulcers may occur with prolonged usage.
Caution: No specific caution is indicated for the Atovaquone and Proguanil HCI in pregnancy and young animals.